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Jun262 weeks agoVisualizing granule integration in the salivary glands of live mice, Milberg et al. reveal that myosin IIA and IIB act at different stages of actomyosin contractilit...
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Jun051 month agoKarg et al. reveal that, in Drosophila melanogaster neuroblasts, acentric chromosomes segregate along interpolar microtubules at the spindle periphery... (more)
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May012 months agoDing et al. reveal that, in the C. elegans zygote, the actin cross-linking protein plastin optimizes connectivity within the cortical actomyosin network... (more)
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Apr033 months agoChowdhury et al. reveal that Chlamydia mitigates oxidative stress by down-regulating the mitochondrial fission protein DRP1 via a microRNA- and p53-dependent pathway...
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Mar064 months agoMoradi et al. reveal that α-, β-, and γ-actin have different functions in motoneuron axons... (more)
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Feb065 months agoEbner et al. use a novel reporter to show that endogenous mTORC2 activity localizes to plasma membrane, mitochondrial, and endosomal pools with distinct sensitivitie...
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Jan026 months agoPetrie et al. reveal that tumor cells with high levels of matrix metalloproteinase activity generally migrate by forming lamellipodia but can also switch to the nucl...
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Dec197 months agoHsu et al. reveal that, by promoting the granules' directed secretion at the immunological synapse, convergence both enhances the efficiency of target cell ...
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Nov218 months agoMurugesan et al. reveal that the medial region of the synapse contains a contractile network of formin-generated actomyosin arcs that sweep T cell receptor microclus...
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Oct249 months agoIcha et al. reveal that, in the zebrafish retina, RGC translocation is expedited by basal process attachment and a population of stable microtubules.... (more)
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Sep2610 months agoIn erythroid cells, endocytosed iron is directly transferred into mitochondria at dynamic endosome–mitochondria contacts. Das et al. reveal that this process a...
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Aug2910 months agoDolat and Spiliotis reveal that septin filaments promote macropinosome maturation and lysosomal delivery by facilitating macropinosome/endosome fusion.... (more)
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Aug0111 months agoBernabé-Rubio et al. reveal that, in polarized MDCK cells, a remnant of the cytokinetic midbody moves to the center of the apical surface, where it encounters...
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Jul041 year agoZhou et al. reveal that enhancing mitochondrial transport in mature neurons rescues energy deficits and facilitates axon regeneration after injury.... (more)
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Jun061 year agoSzabó et al. reveal that the extracellular matrix protein versican confines neural crest cells to enhance their collective migration during Xenopus ...
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May091 year agoHeusermann et al. reveal that exosomes "surf" along recipient cell filopodia before being efficiently endocytosed and targeted to the endoplasmic ...
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Apr111 year agoSac1 is an integral ER membrane protein, but Dickson et al. reveal that it localizes to dynamic ER–plasma membrane contact sites to regulate plasma membrane PI...
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Mar141 year agoDuring Drosophila oogenesis, the collective migration of egg chamber follicle cells drives the chambers' rotation and elongation.... (more)
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Feb151 year agoThough stem cells transplanted into heart attack patients can develop into cardiomyocytes and integrate with undamaged host tissue, preclinical studies and clinical ...
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Jan181 year agoCollective cell migration is an important process in normal development, wound repair, and tumor metastasis.... (more)